Christopher Brower, Ph.D.

Chris Brower portrait

Assistant Professor

Office Location: GRB 323
Office Phone: 940-898-2706
Lab Phone: 940-898-2370
Fax: 940-898-2382
Email: CBrower@twu.edu 

Teaching Areas: Molecular Biology, Cell Biology, Genetics

Research Areas: Gene Regulation, Protein Modification, Protein Degradation

Education

Degree Date Institution Field
Postdoc   2001-2007   California Institute of Technology Biology
Ph.D. 1998-2001 University of Oklahoma Health Science Ctr. Biochemistry & Molecular Biology
M.S. 1996-1998 University of Oklahoma Health Science Ctr.   Biochemistry & Molecular Biology
B.S. 1990-1994 Northeastern Oklahoma State University Biology

Major Academic/Research Interests

My broad scientific interests include the ubiquitin proteasome system and how proteolytic degradation contributes to cellular biology, mammalian physiology, and human disease.

Select Publications

  1. Brower C.S., Piatkov K., and Varshavsky A. (2013) Neurodegeneration-Associated Protein Fragments As Short-Lived Substrates of the N-End Rule Pathway. Molecular Cell, 50:161-71.
  2. Piatkov K.I.*, Brower C.S.* and Alexander Varshavsky (2012) The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments. Proc. Natl. Acad. Sci. USA. PMID: 22670058.* Equal contribution.
  3. Brower C.S., Veiga, L., Jones, R.H., Varshavsky A. (2010) Mouse Dfa is a repressor of TATA-box promoters and interacts with the Abt1 activator of basal transcription. J Biol Chem.285:17218-34.