Hynds, Dianna, Ph.D.
Associate Professor
Biology
PO Box 425799
Texas Woman's University
Denton, TX 76204-5799
Office Location: GRB 104
Office Phone: 940-898-2359
Lab Phone: 940-898-2741
Fax: 940-898-2382
Email: dhynds@twu.edu
Teaching Area: Neuroanatomy and Neurophysiology, Biology Seminar, Signal Transduction
Research Area: Mechanisms of Axon Growth and Guidance
Education
|
B.S. |
1991 |
Hillsdale College |
Biology and Math |
| Ph.D. | 1997 | Ohio State University | Pathobiology |
| Postdoc. | 1997-2000 | Univ. of Kentucky Med. Ctr. | Neurobiology |
Major Academic/Research Interest
Keywords
Our research is focused on elucidating the signal transduction mechanisms the mediate
axon growth and guidance in neurons. This work is important for understanding both
normal neuron development as well as for developing therapeutic strategies to improve
function after traumatic or neurodegenerative disease. Axon growth and guidance are
mediated by rearrangements of the cytoskeleton in a specialized structure located at the
tip of an extending axon called the growth cone. We are currently investigating the role
that small guanine nucleotide triphosphatases (GTPases) of the Rho subfamily play in
axon growth and guidance by dissecting their mechanisms of activation, effect on growth
cone extension and navigation, and regulation of cytoskeletal dynamics in growth cones.
Project List
- Rho GTPase Regulation of Nucleation Complexes of Actin Binding Proteins
- Role of Prenylation in Rho GTPase Activation, Signaling and Subsequent Neurite Outgrowth
- Adhesion Complexes in Axon Growth and Guidance
- Nanoparticle System to Image and Manipulate Axon Growth and Guidance
Select Publications
Selected publications:
- Ghosh S., Cai T., *GhoshMitra S., Hu Z., Diercks D., Mills N.C. and Hynds D.L. (2010) Alternating Magnetic Field Controlled, Multifunctional Nano-reservoirs: Intracellular Uptake and Improved Biocompatibility Nanoscale Res. Lett. 5: 195-204.
- *Seifert J.L., *Som S., and Hynds D.L. (2009) Differential Activation of Rac1 and RhoA in Neuroblastoma Cell Fractions. Neurosci. Lett. 450(2): 176-180.
- Hynds D.L., Rangappa N., Ter Beest J.M., Snow D.M., and Rabchevsky A.G. (2004) Microglia Enhance Dorsal Root Ganglion Outgrowth. Glia 46(2): 218-223.
- Hynds D.L., Spencer M., Andres D.A., and Snow D.M. (2003) Rit Promotes MEK-Independent Neurite Branching in Human Neuroblastoma Cells. J. Cell Sci. 116 (10): 1925-1935.
- Hynds D.L. and Snow D.M. (2002) A Semi-Automated Image Analysis Method to Quantify Neurite Preference/Axon Guidance on a Patterned Substratum. J. Neurosci. Methods 121(1): 53-64.
- Johnson W.E.B., Caterson B., Eisenstein S.M., Hynds D.L., Snow D.M., and Roberts S. (2002) Human Intervertebral Disc Aggrecan Inhibits Nerve Growth In Vitro. Arthritis Rheum. 46(10): 2658-2664.
- Hynds D.L., Takehana A., Inokuchi J., and Snow D.M. (2002) L- and D- Threo-1-Phenyl-2-Decanoylamino-3-Morpholino-1-Propanol (PDMP) Inhibit Neurite Outgrowth from SH-SY5Y Cells. Neuroscience 114(3): 731-744.
- Hynds D.L. and. Snow D.M. (2001) Fibronectin or Laminin Elicits Differential Behaviors from SH-SY5Y Growth Cones Contacting Chondroitin Sulfate Proteoglycans. J. Neurosci. Res. 66(4): 630-642.
- Snow D.M., Mullins N., and Hynds D.L. (2001) Neural-derived Chondroitin Sulfate Proteoglycans Regulate Growth Cone Morphology and Inhibit Neurite Outgrowth: a Light Epifluorescence, and Electron Microscopy Study. Microsc. Res. Tech. 54(5): 273-286.
Courses and Teaching Responsibilities
Keywords
Project List
page last updated 5/2/2012 8:59 AM